Since primary tumors of the heart are rare (see, e.g., 5th ed. of this book, p569), I wish to raise the following question.

Can we induce transplantable ectodermal cells by overexpressing human Toll-like receptor 3 (TLR3), which binds to mRNA, in human cardiomyocytes?

Addendum primum:

I wish to raise the following question about Fig. 4 of this paper.

Can we verify the model using AFM in solution?

Addendum secundum:

A second binding site for dsRNA in human TLR3 has been reported.