I wish to raise the following four questions on human low-density lipoprotein receptor-related protein 4 (hLRP4).
1. What is (are) its ligand(s)?
2. Is the complex consisting of hLRP4 and its ligand(s) endocytosed?
In the following two questions, I assume that the complex is endocytosed and the resultant endosome is translocated to lysosome.
3. Is the endosome a kind of “signaling endosome“?
4. What translocates the endosome to lysosome?