Impressive paper in biology: part 16

Despite the recent advances in regeneration medicine based on reprogramming approach, I find this paper impressive, because the methods employed in it are free of the concern about potential tumorigenicity.


See also here.

Addendum primum:

This paper describes a method dispensing with the Myc-retrovirus.

Addendum secundum:

Sickle-cell anemic mice treated with induced pluripotent stem (iPS) cells didn’t develop tumors after three months of the transplant. So I wish to raise the following question:

Is iPS cell method appropriate for the treatment of human disease(s)?

Addendum tertium:

I wish to raise another question:

Will some researchers test iPS cell transplantation approaches with monkeys?

Addendum quartum:

For the use of common marmosets, see, e.g., here and here.

Addendum quintum:

OK…. Let us watch for progress in iPS cell research.

Addendum sextum:

Unfortunately, in chimeric experiments in mice, c-Myc induces tumors in ca. 20% of subsequent offspring.

Addendum septimum:

By the way, SATB1 has been reported to reprogram gene expression to promote breast tumor growth and metastasis.

Addendum octavum:

Two-factor iPS cell method has been reported.

Addendum nonum:

iPS cells from adult mouse liver cells caused tumor.

Addendum decimum:

Plasmid-induced iPS cells have been reported.

Addendum undecimum:

Who will be the first to succeed in cell transplantation?

Addendum duodecimum:

By the way, common marmoset model seems promising.

Addendum tertium decimum:


Of course, mature cells can be reprogrammed to become pluripotent.