SM-216289 is a strong and specific semaphorin 3A (Sema3A) inhibitor, which leads me to raise the following two questions:
1. Does SM-216289 bind to human Sema3A (hSema3A)?
2. If so, can we measure the binding force between them using AFM in solution?
This posting might be reminiscent of “Neuropilins“, one of my previous postings.
For immunohistochemical analysis of hSema3A, see here.
For the dysfunction of sympathetic innervation following Sema3a disruption, see here.
A typo corrected.