c-kit and its ligand

Perhaps this posting is reminiscent of “ephrin-B2 and EphB2“, one of my previous postings.

Human soluble stem cell factor (SCF)-c-kit ectodomain complex has been crystallized, although there are two types of SCF, i.e., membrane-bound and soluble. So I wish to restrict my attention to isoform 2 of human SCF and raise the following question:

Can we measure the binding force between full-length isoform2 of human SCF and c-kit using AFM in solution?


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