It has been reported that human Kv channel-interacting protein 1 (KChIP1) and cytoplasmic N-terminus of voltage-gated potassium channel Kv4.3 form an octameric complex. So I wish to raise the following two questions:

1. Can we determine the stoichiometry of full-length human DREAM (KChIP3)Kv4.2 complex using AFM in solution?

2. Can we observe the gating of the above complex using AFM in solution?

Addendum primum:

For the involvement of KChIP2 in ventricular tachycardia, see here.

Addendum secundum:

Does human DREAM function as an ion channel in the nuclear membrane?