Musashi-1

This posting is related to “Notch“, one of my previous postings.

Human Musashi-1 (hMSI1) is expressed not only in fetal/adult brain but also in adult pancreas

. And in adult rat hippocampal cells, its ortholog exists in both the nucleus and the cytoplasm

.

So I wish to raise the following three questions:

1. How is the histological distribution of hMSI1 in adult pancreas?

2. Is subcellular localization of hMSI1 in adult pancreatic cells similar to that of rat MSI1 in adult hippocampal cells?

3. If so, can we observe hMSI1’s translocation from the nucleus to the cytoplasm using AFM in solution?

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