Whether interferon-γ (IFN-γ)‘s two receptors IFN-γR1 and IFN-γR2 are preassociated has been controversial. So can we dispense with fluorescent protein such as GFP and settle the controversy using AFM in solution?

Addendum primum:

This article, whose full text I have just obtained, reminds me of the important role played by Janus kinases.