Sprouty 2

D. melanogaster Sprouty antagonizes fibroblast growth factor signaling, thereby suppressing tracheal branching, whereas human Sprouty 2 (hSPRY2) is translocated to membrane ruffles upon epidermal growth factor (EGF) stimulation and spatially regulates EGF signaling.

So I wish to raise the following three questions:

1. Is hSPRY2 involved in congenital atresia of the esophagus?

2. Is there any involvement of motor protein in the translocation of hSPRY2?

3. If such motor protein exists, can we observe its movement using AFM in solution?

Addendum primum:

I have recently noticed a paper demonstrating that SPRY1 knock-out mice exhibit abnormalities resembling human congenital anomalies of the kidney and urinary tract.

Addendum secundum:

The fourth question: Does this paper have something to do with Question 1?

Addendum tertium:

The fifth question: Does hSPRY5 exist?

Addendum quartum:

The sixth question: Does this paper have something to do with Question 2?

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