Small-conductance calcium-activated potassium channel

This posting is related to the previous posting “NMDA receptor“.

Small-conductance calcium-activated potassium channel (SK channel) colocalizes with NMDAR in rat lateral amygdala, making a complex with Ca2+/calmodulin. And there are three kinds of human SK channel subunits, i.e., SK1, SK2, and SK3.

So I wish to raise the following three questions:

1. Is SK channel heteromer in human lateral amygdala composed of SK2 and SK3? (for the distribution of SK1-3 in rat brain, see here.)

Assuming that the heteromer is SK2/SK3,

2. Can we coexpress SK2/SK3 and Ca2+/calmodulin with Xenopus laevis oocyte and observe the gating of SK2/SK3 intracellularly complexed with Ca2+/calmodulin using AFM in solution?

3. Can we observe the interaction between human NMDAR and SK2/SK3 complexed with Ca2+/calmodulin by expressing them likewise and using AFM in solution?


For a recent use of POV-Ray in structural biology, see here.


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