This posting is related to the previous posting “NMDA receptor“.
Small-conductance calcium-activated potassium channel (SK channel) colocalizes with NMDAR in rat lateral amygdala, making a complex with Ca2+/calmodulin. And there are three kinds of human SK channel subunits, i.e., SK1, SK2, and SK3.
So I wish to raise the following three questions:
1. Is SK channel heteromer in human lateral amygdala composed of SK2 and SK3? (for the distribution of SK1-3 in rat brain, see here.)
Assuming that the heteromer is SK2/SK3,
2. Can we coexpress SK2/SK3 and Ca2+/calmodulin with Xenopus laevis oocyte and observe the gating of SK2/SK3 intracellularly complexed with Ca2+/calmodulin using AFM in solution?
3. Can we observe the interaction between human NMDAR and SK2/SK3 complexed with Ca2+/calmodulin by expressing them likewise and using AFM in solution?