BRCA proteins

BRCA1, BRCA2, and BARD1 are involved in the suppression of tumorigenesis in such organs as breast, ovary, and so forth. Besides tumor suppression, both BRCA1/BARD1 heterodimer and BRCA2 have recently been shown to be involved in cytokinesis. (see here and here.)

So I wish to raise the following two questions:

1. Do they interact with microtubule via certain motor proteins?

2. If so, can we identify them by e.g. yeast two-hybrid method and then observe their motion using AFM in solution?


Later, I will discuss adenomatous polyposis coli protein (APC), which binds to KAP3, an associated protein of KIF3A/3B motor protein.


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