BRCA1, BRCA2, and BARD1 are involved in the suppression of tumorigenesis in such organs as breast, ovary, and so forth. Besides tumor suppression, both BRCA1/BARD1 heterodimer and BRCA2 have recently been shown to be involved in cytokinesis. (see here and here.)
So I wish to raise the following two questions:
1. Do they interact with microtubule via certain motor proteins?
2. If so, can we identify them by e.g. yeast two-hybrid method and then observe their motion using AFM in solution?