UNC-14

C. elegans UNC-14, along with kinase UNC-51, regulates the subcellular localization of UNC-5 in neurons by an unknown mechanism and binds to UNC-16-KLC-2 complex through its RUN domain. Assuming that its human ortholog exists, I wish to raise the following two questions:

1. Does putative human ortholog of UNC-14 bind to JIP-3 (human ortholog of UNC-16)-KLC1 complex?

2. Can we observe how it regulates the axonal transport of netrin-1 receptors using AFM in solution?

Remembering Sunday driver protein (SYD) mentioned in “Conventional kinesin“, one of my previous postings, and assuming that UNC-14‘s D. melanogaster ortholog exists, I wish to raise two additional questions:

3. Does putative D. melanogaster ortholog of UNC-14 bind to SYD (D. melanogaster ortholog of UNC-16)-KLC complex?

4. Can we observe how it regulates the axonal transport of Unc5 netrin receptor using AFM in solution?

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