Being a member of the Kinesin-13 family, murine KIF2A suppresses collateral branch extension of the neuron, and murine mitotic centromere-associated kinesin (MCAK) , which is also a member of the Kinesin-13 family, has already been crystallized.
So I wish to raise the following three questions:
2. Can we identify the vesicle(s) it transports more specifically than its murine ortholog’s case?
3. Does it antagonize human netrin-1‘s axon guidance function by some unknown mechanism(s)?
Two possibilities about functional overlapping between human KIF2A and KIF2B have been raised.