NMDA receptor

Glutamate (Glu) is an excitatory neurotransmitter, whose receptors include N-methyl-Daspartate receptor (NMDAR), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR), and so forth. Both NMDAR and AMPAR are thought to be heterotetrameric.

In the AMPAR case, it has been known that if you coexpress Glu receptors 1 and 2, constituents of AMPAR, then they assemble to preferentially form a “symmetric” tetramer.

What about the assembly of NMDAR composed of full-length NR1 and NR2B, then? Current status of our understanding on its stoichiometry and assembly leads me to think that it is worth trying to determine them using AFM in solution.

Addendum primum:

I have recently noticed “symmetric” tetramer model of NR1-NR2B complex.

Addendum secundum:


I have fixed the link pointing to a paper in Neuron.


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