Although I have found work by Sato, C. et al. to be conducive to our understanding of sodium ion transport mechanism across the cell membrane, this kind of research usually provides us with static pieces of information.

So can we observe the open-close cycle of full-length human SCN1A (with or without its accessory proteins) using AFM in solution?

Addendum primum:

Some findings about mice carrying Scn1a mutation have just been reported