An antagonist of bone morphogenetic protein (BMP)-7, noggin has been implicated in osteoblastic response induced by the bone metastasis of prostate cancer. Besides noggin, sclerostin and uterine sensitization-associated gene 1 protein (USAG-1) have been reported to be antagonists. So I wish to raise the following three questions:
1. Have we already identified all BMP-7 antagonists?
Now let us restrict our attention to human normal prostate, where BMP type ⅠB and Ⅱ receptors are expressed.
3. Can we determine the stoichiometry and assembly of the protein complex composed of full-length human BMP-7-noggin-sclerostin-USAG-1-BMP type ⅠB receptor-type Ⅱ receptor with or without as-yet-unidentified antagonist using AFM in solution?
I have just found this paper slightly surprising.
I have just noticed this paper.
Does human anti-dorsalizing morphogenic protein exist?
I have just found this paper a bit surprising.
I have fixed the links pointing to ExPASy.